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Great discussion on HIV & inflammatory bowel disease (IBD). The two major phenotypes of inflammatory bowel disease are ulcerative colitis and Crohns disease. IBD is influenced by a complex interplay of genetics and immunologic factors. However, the exact etiology is unknown. Research on IBD includes focus on particular gut proteins and immune cells that are recruited to the gut. Stem cell research is a focus as well. What role does genetics play in the development of these disorders?